Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

► MPTP is widely used as a model for Parkinson's disease. ► EGb761 is a well-defined mixture of active compounds extracted from Ginkgo biloba. ► EGb761 regulates dopamine-related genes altered by MPTP neurotoxicity. ► Tyrosine hydroxylase- and Nurr1- mRNA were regulated by EGb761. ► Neuroprotection of EGb761 in MPTP involves regulation of dopamine-related genes.