Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis

► Dicer loss causes mis-localized progenitor cells and disorganized cortical lamina. ► Dicer ablation reduces cell cycle kinetics in the developing cortex. ► Without Dicer there is early cell death in the developing cerebral cortex. ► Dicer loss causes dysregulated differentiation and migration markers. ► Dicer depletion causes a precocious induction of astrocyte differentiation.