کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338317 1614855 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus
چکیده انگلیسی

Delta opioid receptors participate to the control of chronic pain and emotional responses. Recent data also identified their implication in spatial memory and drug-context associations pointing to a critical role of hippocampal delta receptors. We examined the distribution of delta receptor-expressing cells in the hippocampus using fluorescent knock-in mice that express a functional delta receptor fused at its carboxyterminus with the green fluorescent protein in place of the native receptor. Colocalization with markers for different neuronal populations was performed by immunohistochemical detection. Fine mapping in the dorsal hippocampus confirmed that delta opioid receptors are mainly present in GABAergic neurons. Indeed, they are mostly expressed in parvalbumin-immunopositive neurons both in the Ammon’s horn and dentate gyrus. These receptors, therefore, most likely participate in the dynamic regulation of hippocampal activity.

Figure optionsDownload high-quality image (60 K)Download as PowerPoint slideHighlights
► Fluorescent knock-in mice were used to map delta opioid receptor distribution.
► Delta opioid receptors are present in all hippocampal areas.
► Hippocampal delta opioid receptors are primarily expressed in GABAergic neurons.
► Delta opioid receptors are mostly identified in parvalbumin-positive neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 221, 27 September 2012, Pages 203–213
نویسندگان
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