کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338419 1614865 2012 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The science of making drug-addicted animals
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The science of making drug-addicted animals
چکیده انگلیسی

Research involving animal models of drug addiction can be viewed as a sort of reverse psychiatry. Contrary to clinicians who seek to treat addicted people to become and remain abstinent, researchers seek to make drug-naïve animals addicted to a drug with known addictive properties in humans. The goals of this research are to better understand the neuroscience of drug addiction and, ultimately, to translate this knowledge into effective treatments for people with addiction. The present review will not cover the vast literature that has accumulated over the past 50 years on animal models of drug addiction. It is instead more modestly devoted to recent research spanning the past decade on drug self-administration–based models of addiction in the rat (the animal species most frequently used in the field), with a special focus on current efforts to model compulsive cocaine use as opposed to nonaddictive use. Surprisingly, it turns out that modeling compulsive cocaine use in rats is possible but more difficult than previously thought. In fact, it appears that resilience to cocaine addiction is the norm in rats. As in human cocaine users, only few individual rats would be vulnerable. This conclusion has several important implications for future research on the neuroscience of cocaine addiction and on preclinical medication development.This article is part of a Special Issue entitled: Neuroscience Disease Models.

▶Recent research involving animal models of addiction is reviewed. ▶With a special focus on models of compulsive cocaine use in rats. ▶Compulsive cocaine use is possible but difficult to model in rats. ▶Resilience to cocaine addiction is the norm. ▶Only few individual rats seem vulnerable to addiction. ▶Implications for future research on the neuroscience of addiction are drawn.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 211, 1 June 2012, Pages 107–125
نویسندگان
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