کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338564 1614875 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse
چکیده انگلیسی

The superior paraolivary nucleus (SPON; alternative abbreviation: SPN for the same nucleus in certain species) is a prominent brainstem structure that provides strong inhibitory input to the auditory midbrain. Previous studies established that SPON neurons encode temporal sound features with high precision. These earlier characterizations of SPON responses were recorded under the influence of ketamine, a dissociative anesthetic agent and known antagonist of N-methyl-d-aspartate glutamate (NMDA) receptors. Because NMDA alters neural responses from the auditory brainstem, single unit extracellular recordings of SPON neurons were performed in the presence and absence of ketamine. In doing so, this study represents the first in vivo examination of the SPON of the mouse. Herein, independent data sets of SPON neurons are characterized that did or did not receive ketamine, as well as neurons that were recorded both prior to and following ketamine administration. In all conditions, SPON neurons exhibited contralaterally driven spikes triggered by the offset of pure tone stimuli. Ketamine lowered both evoked and spontaneous spiking, decreased the sharpness of frequency tuning, and increased auditory thresholds and first-spike latencies. In addition, ketamine limited the range of modulation frequencies to which neurons phase-locked to sinusoidally amplitude-modulated tones.

▶We recorded from SPON neurons in mouse in the presence and absence of ketamine. ▶Ketamine lowered evoked and spontaneous spiking in SPON neurons. ▶Ketamine increased auditory thresholds and first-spike latencies in SPON neurons. ▶Ketamine descreased spike count and response synchronization to SAM stimuli.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 201, 10 January 2012, Pages 307–319
نویسندگان
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