کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338784 1614885 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update
چکیده انگلیسی

Despite decades of laboratory research and clinical trials, a safe and effective treatment for traumatic brain injury has yet to reach clinical practice. The failure is due in part to the prevalence of a reductionist philosophy and research praxis that targets a single receptor mechanism, gene, or brain locus. This approach fails to account for the fact that traumatic brain injury is a very complex disease caused by a cascade of systemic toxic events in the brain and throughout the body. Attention is now turning to pleiotropic drugs that act on multiple genomic, proteomic, and metabolic pathways to enhance morphological and functional outcomes after brain injury. Of the agents now in clinical trial, the neurosteroid progesterone appears to hold considerable promise. Many still assume that progesterone is “just a female hormone” with limited, if any, neuroprotective properties, but this view is outdated. This review will survey the evidence that progesterone has salient pleiotropic properties as a neuroprotective agent in a variety of central nervous system injury models.This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain.

▶Progesterone shows neuroprotective effects after traumatic brain injury in animals and humans. ▶Progesterone showed beneficial effects in two phase II trials for traumatic brain injury. ▶Progesterone is now in two phase III trials in the USA, Europe, and Asia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 191, 15 September 2011, Pages 101–106
نویسندگان
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