The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

▶The majority of PGP 9.5 nerve fibers in bone express TrkA. ▶The majority of CGRP+ and NF200+ nerves in bone express TrkA. ▶High TrkA innervation in bone may provide an opportunity to treat bone pain.