کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4339907 | 1295773 | 2009 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Compartmentation of the cerebellar nuclei of the mouse
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کلمات کلیدی
PBSMBPeGFPGLYT2Zebrin IITbr1phosphate buffer - بافر فسفاتβ-galactosidase - بتا گالاکتوزیدازPurkinje cell - سلول پورکنژ، یاخته پورکینیهphospholipase C - فسفولیپاز Cstripe - نوارcerebellar nuclei - هسته مخچهenhanced green fluorescent protein - پروتئین فلورسنت سبز افزایش یافته استmaltose binding protein - پروتئین متصل به مالتوزglycine transporter 2 - گلیسین حمل کننده 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Compartmentation of the cerebellar nuclei of the mouse Compartmentation of the cerebellar nuclei of the mouse](/preview/png/4339907.png)
چکیده انگلیسی
The cerebellar nuclei integrate inhibitory input from Purkinje cells with excitatory input from mossy and climbing fiber collaterals and are the sole cerebellar output. Numerous studies have shown that the cerebellar cortex is highly compartmentalized into hundreds of genetically determined, reproducible topographic units-transverse zones and parasagittal stripes-that can be identified through the expression patterns of numerous molecules. The Purkinje cell stripes project to the cerebellar nuclei. However, there is no known commensurate topographic complexity in the cerebellar nuclei. Rather, conventional anatomical descriptions identify four major subdivisions-the medial, anterior and posterior interposed, and lateral nuclei-together with a few intranuclear subdivisions. To begin to address the apparent complexity gap, we have used a panel of antigens and transgenes to reveal a reproducible molecular heterogeneity in the mouse cerebellar nuclei. Based on the differential expression patterns, singly and in combination, a new cerebellar nuclear topographic map has been constructed. This reveals the subdivision of the cerebellar nuclei into at least 12 reproducible expression domains. We hypothesize that such heterogeneity is the counterpart of the zones and stripes of the cerebellar cortex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 161, Issue 1, 16 June 2009, Pages 123-138
Journal: Neuroscience - Volume 161, Issue 1, 16 June 2009, Pages 123-138
نویسندگان
S.-H. Chung, H. Marzban, R. Hawkes,