کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4340082 1295782 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nexin-1 inhibits the activity of human brain trypsin
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Nexin-1 inhibits the activity of human brain trypsin
چکیده انگلیسی

Trypsin and other trypsin-like serine proteases have been shown to play important roles in neural development, plasticity and neurodegeneration. Their activity is modulated by serine protease inhibitors, serpins. However, for human brain trypsin, trypsin-4, no brain-derived inhibitors have been described. Here, we report that nexin-1 inhibits trypsin-4, and forms stable complexes only with this trypsin-isoenzyme. This result suggests that nexin-1 could modulate trypsin activity in brain where both nexin-1 and trypsin-4 are expressed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 160, Issue 1, 21 April 2009, Pages 97–102
نویسندگان
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