Early frequency-dependent information processing and cortical control in the whisker pathway of the rat: Electrophysiological study of brainstem nuclei principalis and interpolaris

The rat facial whiskers form a high-resolution sensory apparatus for tactile information coding and are used by these animals for the exploration and perception of their environment. Previous work on the rat vibrissae system obtained evidence for vibration-based feature extraction by the whiskers, texture classification by the cortical neurons, and “low-pass,” “high-pass,” and “band-pass” filtering properties in both thalamic and cortical neurons. However, no data are available for frequency-dependent information processing in the brainstem sensory trigeminal complex (STC), the first relay station of the vibrissae pathway. In the present paper, we studied the frequency-dependent processing characteristics of the STC nuclei that mainly project to the thalamus, nuclei principalis, and interpolaris. This is the first time that STC nuclei have been studied together via a wide range of stimulation frequencies (1-40 Hz), four different and complementary metrics, and the same experimental protocol. Moreover, the role of corticofugal projection to these nuclei as well as the influence of input from the whiskers has been analyzed. We show that both nuclei perform frequency-dependent coding of tactile information: low pass and band-pass filtering occurs for the spiking rate in short post-stimuli time intervals, high-pass and band-pass filtering occurs for the spiking rate in long trains of stimuli, and an increase of response latencies and low pass filtering occurs for phase-locked stimuli. These information-processing characteristics are neither imposed by the sensorimotor cortex nor introduced by the afferent fibres. The sensorimotor cortex exerts a distinct modulatory effect on each nucleus.