کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4340292 1295789 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11
چکیده انگلیسی

In this study, we examined protein–protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and sorLA/LR11, and found that these receptors interact, as indicated by three independent lines of evidence: co-immunoprecipitation experiments on mouse brain extracts and mouse neuronal cells, surface plasmon resonance analysis with purified human LRP and sorLA, and fluorescence lifetime imaging microscopy (FLIM) on rat primary cortical neurons. Immunocytochemistry experiments revealed widespread co-localization of LRP and sorLA within perinuclear compartments of rat primary neurons, while FLIM analysis showed that LRP-sorLA interactions take place within a subset of these compartments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 4, 18 February 2009, Pages 1460–1468
نویسندگان
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