کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4340354 1295790 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influences of surgical decompression on the dorsal horn after chronic constriction injury: Changes in peptidergic and δ-opioid receptor (+) nerve terminals
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Influences of surgical decompression on the dorsal horn after chronic constriction injury: Changes in peptidergic and δ-opioid receptor (+) nerve terminals
چکیده انگلیسی

To understand plastic changes in the dorsal horn related to neuropathic pain, we developed a model of decompression in rats with chronic constriction injury (CCI) and investigated corresponding changes in the dorsal horn. At postoperative week 4 (POW 4) of CCI, rats were divided into a decompression group, in which ligatures were removed, and a CCI group, in which ligatures remained. Spinal cords were immunostained for substance P (SP), the δ-opioid receptor (DOR), and calcitonin gene-related peptide (CGRP). Areas of immunoreactive nerve terminals in the dorsal horn were quantified and expressed as the dorsal horn index (immunoreactive areas of the operated side compared with those of the contralateral side). At POW 4, dorsal horn indexes of all of these molecules were significantly reduced in both groups to similar degrees (0.36∼0.43). At POW 8, neuropathic pain behaviors had completely disappeared in the decompression group with significant reversal of the dorsal horn indexes compared with the CCI group (0.81±0.02 vs. 0.58±0.09, P<0.001 for SP and 0.75±0.04 vs. 0.55±0.03, P<0.001 for DOR). In the CCI group, neuropathic pain behaviors became normalized at POW 12 with corresponding changes in dorsal horn indexes for both SP and DOR similar to those of the decompression group. In contrast, changes in the dorsal horn indexes of CGRP were similar in both the CCI and decompression groups throughout the experimental period. These findings suggest that CCI and decompression cause different patterns in peptidergic and DOR (+) nerve terminals in the dorsal horn.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 156, Issue 3, 15 October 2008, Pages 758–768
نویسندگان
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