کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340427 | 1295794 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CPPGFAPGADPBSc-fos immunoreactivityHDBglutamic acid decarboxylase - glutamic acid dearboxylaseACh - آهAcetylcholine - استیل کولینhorizontal limb of the diagonal band of Broca - اندام افقی از گروه مورب Brocaphosphate buffer - بافر فسفاتVisual discrimination - تبعیض بصریVisual acuity - حدت بینایی Cholinergic system - سیستم CholinergicParvalbumin - پاروالبومینGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالChAT - چتcholine acetyltransferase - کولین استیل ترانسفرازMuscarinic receptor - گیرنده Muscarinic
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates](/preview/png/4340427.png)
چکیده انگلیسی
Acetylcholine is released in the primary visual cortex during visual stimulation and may have a neuromodulatory role in visual processing. The present study uses both behavioral and functional neuroanatomy investigations to examine this role in the rat. In the first set of experiments the cholinergic system was lesioned with 192 immunoglobulin G (IgG) saporin and the visual acuity and performance in a visual water maze task were assessed. The cholinergic lesion did not affect the visual acuity measured pre- and post-lesion but it did reduce the efficiency to learn a novel orientation discrimination task measured post-lesion. In order to better understand the involvement of the cholinergic system in the neuronal activity in the visual cortex c-Fos expression induced by patterned visual stimulation was further investigated. Results obtained following lesion of the cholinergic fibers (192 IgG-saporin or quisqualic acid), muscarinic inhibition (scopolamine), or NMDA receptor inhibition (CPP) were compared with control conditions. Double and triple immunolabeling was used in order to determine the neurochemical nature of the activated cortical cells. The results demonstrated that patterned stimulation elicited a significant increase in c-Fos immunolabeled neurons in layer IV of the contralateral primary visual cortex to the stimulated eye which was completely abolished by cholinergic fibers lesion as well as scopolamine administration. This effect was independent of NMDA receptor transmission. The c-Fos activation was predominantly observed in the glutamatergic spiny stellate cells and less frequently in GABAergic interneurons. Altogether, these results demonstrate a strong involvement of the basal forebrain cholinergic system in the modulation of post-synaptic visual processing, which could be related to cognitive enhancement or attention during visual learning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 154, Issue 4, 17 July 2008, Pages 1607-1618
Journal: Neuroscience - Volume 154, Issue 4, 17 July 2008, Pages 1607-1618
نویسندگان
F. Dotigny, A.Y. Ben Amor, M. Burke, E. Vaucher,