کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340925 | 1295815 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey
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کلمات کلیدی
DAB3,3′diaminobenzidineOFCROIPFC5-HTAnatomy - آناتومیAChE - آهیAcetylcholinesterase - استیل کولین استرازSERT - سختserotonergic - سروتونرژیکSerotonin - سروتونینserotonin transporter - سروتونین حمل کنندهprefrontal cortex - قشر prefrontalorbitofrontal cortex - قشر اوربیتوفرنتالCytoarchitecture - معماری معماریregion of interest - منطقه مورد نظرhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراventromedial prefrontal cortex - کورتکس prefrontal ventromedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To elucidate the organization of the serotoninergic innervation within the orbitofrontal cortex (OFC), serotonin transporter (SERT) density was quantified by autoradiography using [3H]cyanoimipramine binding. In six adult vervet monkeys, 15 architectonic areas were delineated according to cytoarchitectonic (Nissl), myeloarchitectonic (Gallyas) and chemoarchitectonic (acetylcholinesterase) criteria to assess SERT distribution at two levels of organization: cortical area and cortical type. For cortical type, the 15 areas were evenly divided into three different categories primarily based upon the degree of granularization of layer IV: agranular, dysgranular, and granular. Within agranular and dysgranular, but not granular cortical types, SERT density was area-specific and progressively decreased in a medial to lateral gradient. Across cortical types, SERT density decreased in a caudal to rostral gradient: agranular>dysgranular>granular. A similar caudal to rostral gradient was seen when serotonin content was measured (using high performance liquid chromatography) in areas representative of each cortical type. Collectively, these results suggest that the serotoninergic innervation is organized according to both cortical type and area, and is thus structured to differentially modulate information processing within the OFC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 148, Issue 4, 21 September 2007, Pages 937-948
Journal: Neuroscience - Volume 148, Issue 4, 21 September 2007, Pages 937-948
نویسندگان
B.M. Way, G. LaÄan, L.A. Fairbanks, W.P. Melega,