کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341018 | 1614907 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear
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کلمات کلیدی
PBSBLAbasolateral amygdala complexCRFpKaCRF1pCREBCRF2central amygdala nucleuscyclic AMP - AMP cycliccAMP - cAMPCeA - CEACentral amygdala - آمیگدالای مرکزیsodium phosphate buffer - بافر فسفات سدیمlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Contextual fear conditioning - تهدید متضادcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینprotein kinase A - پروتئین کیناز ACorticotropin-releasing factor receptor 1 - گیرنده فاکتور آزاد کننده کورتیکوتروپین 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The basolateral amygdala complex (BLA) and central amygdala nucleus (CeA) are involved in fear and anxiety. In addition, the BLA contains a high density of corticotropin-releasing factor 1 (CRF1) receptors in comparison to the CeA. However, the role of BLA CRF1 receptors in contextual fear conditioning is poorly understood. In the present study, we first demonstrated in rats that oral administration of DMP696, the selective CRF1 receptor antagonist, had no significant effects on the acquisition of contextual fear but produced a subsequent impairment in contextual freezing suggesting a role of CRF1 receptors in the fear memory consolidation process. In addition, oral administration of DMP696 significantly reduced phosphorylation of cyclic AMP response element-binding protein (pCREB) in the lateral and basolateral amygdala nuclei, but not in the CeA, during the post-fear conditioning period. We then demonstrated that bilateral microinjections of DMP696 into the BLA produced no significant effects on the acquisition of conditioned fear but reduced contextual freezing in a subsequent drug-free conditioned fear test. Importantly, bilateral microinjections of DMP696 into the BLA at 5 min or 3 h, but not 9 h, after exposure to contextual fear conditioning was also effective in reducing contextual freezing in the conditioned fear test. Finally, microinfusions of either DMP696 into the CeA or a specific corticotropin-releasing factor 2 receptor antagonist in the BLA were shown to have no major effects on disrupting either contextual fear conditioning or performance of contextual freezing in the drug-free conditioned fear test. Collectively, results implicate a role of BLA CRF1 receptors in activating the fear memory consolidation process, which may involve BLA pCREB-induced synaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 150, Issue 4, 19 December 2007, Pages 818-828
Journal: Neuroscience - Volume 150, Issue 4, 19 December 2007, Pages 818-828
نویسندگان
D.T. Hubbard, B.R. Nakashima, I. Lee, L.K. Takahashi,