کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341281 | 1295829 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anterograde tracing of projections from the dorsal raphe nucleus to the vestibular nuclei
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کلمات کلیدی
ABCDABCTBDRNBDA3,3′-diaminobenzidine tetrahydrochloride - 3،3'-diaminobenzidine tetrahydrochloridebiotinylated dextran amine - بیوترنیته دیستران آمینAnterograde tracing - ردیابی AnterogradeRats - موش صحراییdorsal raphe nucleus - هسته رافهVestibular nuclei - هسته های Vestibularcholera toxin subunit B - کلسترول توکسین B
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study used the anterograde transport of biotinylated dextran amine (BDA) to identify the course and terminal distribution of projections from the dorsal raphe nucleus (DRN) to the vestibular nuclei in rats. After iontophoretic injection of BDA into the medial and lateral regions of DRN, anterogradely labeled fibers descend within the medial longitudinal fasciculus and the ventricular fiber plexus to terminate within two discrete regions of the vestibular nuclear complex. One terminal field was located primarily ipsilateral to the injection site and involved rostrodorsal aspects of the vestibular nuclei, including superior vestibular nucleus and rostral portions of the medial vestibular nucleus (MVN) and lateral vestibular nucleus (LVN). The other terminal field involved caudoventral aspects of both ipsilateral and contralateral MVN and LVN and was less heavily innervated. These findings confirm that the vestibular nuclei are targeted by a regionally-selective projection from the DRN. The segregation of DRN terminals into anatomically distinct fields indicates that the DRN-vestibular nucleus projections are organized to selectively modulate processing within specific functional domains of the vestibular nuclear complex. In particular, these terminal fields may be organized to modulate vestibular regions involved in eye movement-related velocity storage, coordination of vestibular and affective responses, and the bilateral coordination of horizontal eye movement reflexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 143, Issue 2, 1 December 2006, Pages 641-654
Journal: Neuroscience - Volume 143, Issue 2, 1 December 2006, Pages 641-654
نویسندگان
A.L. Halberstadt, C.D. Balaban,