کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341298 | 1295830 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes
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کلمات کلیدی
IL4IFNγTNFαtetrahydrobiopterinBH4LPSforskolinDEXCREFCSTGFβFskiNOScAMP - cAMPIL1β - IL1bNFκB - NFKBinterferon-γ - اینترفرون-γinterleukin-4 - اینترلوکین -4Interleukin-1β - اینترلوکین-1βtransforming growth factor-β - تبدیل فاکتور رشد βtumor necrosis factor-α - تومور نکروز عامل αICD - دفیبریلاتورهای کاردیوورتر کاشتنیDexamethasone - دگزامتازونfetal calf serum - سرم گوساله جنینinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییcAMP response element - عنصر پاسخ cAMPnuclear factor-κB - فاکتور هسته ای κBlipopolysaccharide - لیپوپلی ساکاریدnoradrenaline - نورآدرنالین Nitric oxide - نیتریک اکسیدGlucocorticoid - گلوکوکورتیکوئیدها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes](/preview/png/4341298.png)
چکیده انگلیسی
We previously showed that lipopolysaccharide (LPS) and pro-inflammatory cytokines utilized different mechanisms for the production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) in cultured rat astrocytes. To further characterize these regulatory pathways, we tested the effects of inhibitory factors (anti-inflammatory cytokines, cellular cAMP, and glucocorticoid) on aspects of iNOS expression (from transcription to enzyme activity) during LPS- and cytokine-induced astrocyte NO production. Anti-inflammatory cytokines (transforming growth factor-β and interleukin-4) suppressed both LPS- and cytokine-induced NO production by reducing iNOS protein expression without affecting mRNA levels. Increased cellular cAMP levels, induced by noradrenaline or forskolin, suppressed LPS-induced, but not cytokine-induced, NO production without affecting iNOS protein expression. The glucocorticoid analog, dexamethasone, suppressed LPS-induced, but not cytokine-induced, NO production by reducing iNOS promoter activity. These different mechanisms would allow the fine control of NO concentration in the brain, as well as accounting for the multiple roles of NO in brain physiology and pathology. Moreover, these mechanisms provide useful therapeutic targets for the treatment of neurodegenerative diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 144, Issue 3, 9 February 2007, Pages 911-919
Journal: Neuroscience - Volume 144, Issue 3, 9 February 2007, Pages 911-919
نویسندگان
N. Kozuka, Y. Kudo, M. Morita,