کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341743 | 1295845 | 2006 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcription factor protein expression patterns by neural or neuronal progenitor cells of adult monkey subventricular zone
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کلمات کلیدی
SVZaanterior subventricular zoneGFAPNkxPAXOligNGNCNPDLXTRITC2′,3′-cyclic nucleotide 3′-phosphodiesterase - 2 '، 3'-cyclic نوکلئوتید 3'-فسفودی استراز5-bromo-2′-deoxyuridine - 5-bromo-2'-deoxyuridineSOx - SOXEmx - اکسپرسCerebral ischemia - ایسکمی مغزیBrdU - بروموداکسی اوریدینtetramethylrhodamine isothiocyanate - تترامتییل رودامین ایزوتیوسیاناتpaired-box - زوج جعبهCell fate - سرنوشت سلولیPrimate - نخستیسانان، نخستیها، پریمات هاadult neurogenesis - نوروژنز بزرگسالانneurogenin - نوروژنینGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The anterior subventricular zone of the adult mammalian brain contains progenitor cells which are upregulated after cerebral ischemia. We have previously reported that while a part of the progenitors residing in adult monkey anterior subventricular zone travels to the olfactory bulb, many of these cells sustain location in the anterior subventricular zone for months after injury, exhibiting a phenotype of either neural or neuronal precursors. Here we show that ischemia increased the numbers of anterior subventricular zone progenitor cells expressing developmentally regulated transcription factors including Pax6 (paired-box 6), Emx2 (empty spiracles-homeobox 2), Sox 1-3 (sex determining region Y-box 1-3), Ngn1 (neurogenin 1), Dlx1,5 (distalless-homeobox 1,5), Olig1,3 (oligodendrocyte lineage gene 1,3) and Nkx2.2 (Nk-box 2.2), as compared with control brains. Analysis of transcription factor protein expression by sustained neural or neuronal precursors in anterior subventricular zone revealed that these two cell types were positive for characteristic sets of transcription factors. The proteins Pax6, Emx2, Sox2,3 and Olig1 were predominantly localized to dividing neural precursors while the factors Sox1, Ngn1, Dlx1,5, Olig2 and Nkx2.2 were mainly expressed by neuronal precursors. Further, differences between monkeys and non-primate mammals emerged, related to expression patterns of Pax6, Olig2 and Dlx2. Our results suggest that a complex network of developmental signals might be involved in the specification of primate progenitor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 139, Issue 4, 2006, Pages 1355-1367
Journal: Neuroscience - Volume 139, Issue 4, 2006, Pages 1355-1367
نویسندگان
A.B. Tonchev, T. Yamashima, K. Sawamoto, H. Okano,