کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341755 | 1295845 | 2006 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multisensory plasticity in congenitally deaf mice: How are cortical areas functionally specified?
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کلمات کلیدی
ABRDPOAEAAFNKCC1SPBPMCA2primary auditory areadistortion product otoacoustic emission - انتشار محصولات octo آکوستیک محصول اعوجاجCortical organization - سازماندهی کروماتیکcytochrome oxidase - سیتوکروم اکسیدازEvolution - فرگشت Primary somatosensory area - منطقه اسموتی سوزنی اولیهprimary visual area - منطقه بصری اولیهSecondary somatosensory area - منطقه ثبات سومیوزنسوریauditory brainstem response - پاسخ شنوایی مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The neocortex of congenitally deaf mice was examined using electrophysiological recording techniques combined with cortical myeloarchitecture. Our results indicate that relative activity patterns across sensory systems during development contribute to modality assignment of cortical fields as well as the size of cortical fields. In congenitally deaf mice, “auditory cortex” contained neurons that responded to somatosensory, visual, or both somatosensory and visual stimulation; the primary visual area contained a larger proportion of neurons that responded to somatosensory stimulation than in normal animals, and the primary visual area had significantly increased in size. Thus, cortical architecture and functional specification were de-correlated. When results are considered in the light of molecular studies and studies in which peripheral activity is altered in development, it becomes clear that similar types of changes to the neocortex, such as alterations in cortical field size, can be achieved in more than one way in the developing and evolving neocortex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 139, Issue 4, 2006, Pages 1507-1524
Journal: Neuroscience - Volume 139, Issue 4, 2006, Pages 1507-1524
نویسندگان
D.L. Hunt, E.N. Yamoah, L. Krubitzer,