RETRACTED: Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer’s disease and cerebral amyloid angiopathy

This article has been retracted at the request of the editors and authors. Please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).Reason: After publication of their paper, the authors increased the number of control cases and carried out densitometric studies relating levels of malondialdehyde lysine (MDAL) immunoreactivity to levels of 14-3-3 immunoreactivity in comparative spots of membranes blotted with 14-3-3 and MDAL antibodies. Differences were not significant between Alzheimer's disease (AD) (n=6) and age-matched controls (n=8) when values of MDAL in 14-3-3 spots were corrected by values of total 14-3-3.Therefore, the present data do not indicate significant differences between control and AD cases regarding total 14-3-3 and oxidised 14-3-3 levels in total homogenates, and the conclusion made in this article is invalidated.In the article it was concluded that the 14-3-3 zeta and gamma isoforms are oxidatively damaged in the aged human brain. The latter conclusion is still valid.Santpere G, Ferrer I; Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, carrer Feixa LLarga sn, 08907 Hospitalet de LLobregat, Spain.