کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4341895 1295849 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tolerance development to Morris water maze test impairments induced by acute allopregnanolone
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Tolerance development to Morris water maze test impairments induced by acute allopregnanolone
چکیده انگلیسی

The progesterone metabolite allopregnanolone, like benzodiazepines, reduces learning and impairs memory in rats. Both substances act as GABA agonists at the GABA-A receptor and impair the performance in the Morris water maze test. Women are during the menstrual cycle, pregnancy, and during hormone replacement therapy exposed to allopregnanolone or allopregnanolone-like substances for extended periods. Long-term benzodiazepine treatment can cause tolerance against benzodiazepine-induced learning impairments. In this study we evaluated whether a corresponding allopregnanolone tolerance develops in rats.Adult male Wistar rats were pretreated for 3 days with i.v. allopregnanolone injections (2mg/kg) one or two times a day, or for 7 days with allopregnanolone injections 20mg/kg intraperitoneally, twice a day. Thereafter the rats were tested in the Morris water maze for 5 days and compared with relevant controls. Rats pretreated with allopregnanolone twice a day had decreased escape latency, path length and thigmotaxis compared with the acute allopregnanolone group that was pretreated with vehicle. Pretreatment for 7 days resulted in learning of the platform position. However, the memory of the platform position was in these tolerant rats not as strong as in controls only given vehicle. Allopregnanolone treatment was therefore seen to induce a partial tolerance against acute allopregnanolone effects in the Morris water maze.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 139, Issue 2, 2006, Pages 651–659
نویسندگان
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