کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341989 | 1295852 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Purkinje cell subtype specification in the cerebellar cortex: Early B-cell factor 2 acts to repress the zebrin II-positive Purkinje cell phenotype
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کلمات کلیدی
HspEbf2PLCOMPSphKZebrin IISphingosine kinase - اسپینوزین کینازPattern formation - تشکیل الگوembryonic day - روز جنینیPurkinje cell - سلول پورکنژ، یاخته پورکینیهphospholipase C - فسفولیپاز Ccentral zone - منطقه مرکزیHeat shock protein - پروتئین شوک حرارتolfactory marker protein - پروتئین مارکر بویایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The mammalian cerebellar cortex is highly compartmentalized. First, it is subdivided into four transverse expression domains: the anterior zone (AZ), the central zone (CZ), the posterior zone (PZ), and the nodular zone (NZ). Within each zone, the cortex is further subdivided into a symmetrical array of parasagittal stripes. The most extensively studied compartmentation antigen is zebrin II/aldolase c, which is expressed by a subset of Purkinje cells forming parasagittal stripes. Stripe phenotypes are specified early in cerebellar development, in part through the action of early B-cell factor 2 (Ebf2), a member of the atypical helix-loop-helix transcription factor family Collier/Olf1/EBF. In the murine cerebellum, Ebf2 expression is restricted to the zebrin II-immunonegative (zebrin IIâ) Purkinje cell population. We have identified multiple cerebellar defects in the Ebf2 null mouse involving a combination of selective Purkinje cell death and ectopic expression of multiple genes normally restricted to the zebrin IIâ subset. The nature of the cerebellar defect in the Ebf2 null is different in each transverse zone. In contrast to the ectopic expression of genes characteristic of the zebrin II+ Purkinje cell phenotype, phospholipase Cβ4 expression, restricted to zebrin IIâ Purkinje cells in control mice, is well maintained, and the normal number of stripes is present. Taken together, these data suggest that Ebf2 regulates the expression of genes associated with the zebrin II+ Purkinje cell phenotype and that the zebrin IIâ Purkinje cell subtype is specified independently.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 153, Issue 3, 15 May 2008, Pages 721-732
Journal: Neuroscience - Volume 153, Issue 3, 15 May 2008, Pages 721-732
نویسندگان
S.-H. Chung, H. Marzban, L. Croci, G.G. Consalez, R. Hawkes,