کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4342378 1295865 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons
چکیده انگلیسی

The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of growth cones in hippocampal and spinal neurons, respectively. However, the molecular mechanisms underlying these effects have not been completely elucidated. In the present study, we analyzed the morphological and molecular changes induced by agrin in growth cones of hippocampal neurons that developed in culture. Morphometric analysis showed a significant enlargement of growth cones of hippocampal neurons cultured in the presence of agrin. These agrin-induced growth cone changes were accompanied by the formation of loops of microtubules highly enriched in acetylated tubulin and an increase in the content of the microtubule-associated protein (MAP)1B. Together, these data provide further insights into the potential molecular mechanisms underlying the effects of agrin on neurite outgrowth in rat central neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 149, Issue 3, 9 November 2007, Pages 527–536
نویسندگان
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