کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4351301 1615272 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minimal hepatic encephalopathy: A review
ترجمه فارسی عنوان
حداقل آنسفالوپاتی کبدی: یک بررسی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Minimal hepatic encephalopathy (MHE) can affect up to 80% of patients with cirrhosis.
• MHE is characterized by impairment in attention, vigilance and integrative function.
• MHE affects daily functioning, quality of life, driving and overall mortality.
• Spectral and quantitative analysis of EEG provide early markers of cerebral dysfunction.
• Neuroimaging reveals abnormal organization of functional connectivity networks.

Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy and can affect up to 80% of patients with liver cirrhosis. By definition, MHE is characterized by cognitive function impairment in the domains of attention, vigilance and integrative function, but obvious clinical manifestation are lacking. MHE has been shown to affect daily functioning, quality of life, driving and overall mortality. The diagnosis can be achieved through neuropsychological testing, recently developed computerized psychometric tests, such as the critical flicker frequency and the inhibitory control tests, as well as neurophysiological procedures. Event related potentials can reveal subtle changes in patients with normal neuropsychological performances. Spectral analysis of electroencephalography (EEG) and quantitative analysis of sleep EEG provide early markers of cerebral dysfunction in cirrhotic patients with MHE. Neuroimaging, in particular MRI, also increasingly reveals diffuse abnormalities in intrinsic brain activity and altered organization of functional connectivity networks. Medical treatment for MHE to date has been focused on reducing serum ammonia levels and includes non-absorbable disaccharides, probiotics or rifaximin. Liver transplantation may not reverse the cognitive deficits associated with MHE. We performed here an updated review on epidemiology, burden and quality of life, neuropsychological testing, neuroimaging, neurophysiology and therapy in subjects with MHE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 111, October 2016, Pages 1–12
نویسندگان
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