کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351422 | 1615306 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CAST: Functional scaffold for the integrity of the presynaptic active zone
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Cytomatrix at the active zone (CAZ)-associated structural protein (CAST) was first purified from the synaptic junction fraction of biochemically isolated central nervous system, and initially implicated as a critical component of the active zone. Subsequent biochemical analysis of CAST has shown that CAST potentially form a large molecular complex with other CAZ proteins including RIMs, Munc13s, Bassoon, and Piccolo/Aczonin in nerve terminals. Furthermore, recent genetic approaches using animal models such as C. elegans, Drosophila and mice have revealed that CAST has important functional and organizational roles in the assembly and maintenance of the presynaptic active zone. In this update article, I would like to summarize recent findings that place CAST as a functional scaffold regulating voltage-dependent Ca2+ channels and maintaining the integrity of the presynaptic active zone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 76, Issues 1â2, MayâJune 2013, Pages 10-15
Journal: Neuroscience Research - Volume 76, Issues 1â2, MayâJune 2013, Pages 10-15
نویسندگان
Toshihisa Ohtsuka,