کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4351699 1298077 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Painful muscle stimulation preferentially activates emotion-related brain regions compared to painful skin stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Painful muscle stimulation preferentially activates emotion-related brain regions compared to painful skin stimulation
چکیده انگلیسی

Skin pain and muscle pain are categorically distinct from each other. While skin pain is a sharp, spatially localized sensation, muscle pain is a dull, poorly localized and more unpleasant one. We hypothesized that there are specific brain regions preferentially activated by muscle pain compared to skin pain. To test this hypothesis, brain responses were recorded from 13 normal male subjects in response to repeated painful electrical stimulation of the muscle and skin of the left leg, using 3-T magnetic resonance imaging scanner. The common brain regions that responded to painful stimulations of both skin and muscle were the thalamus, anterior cingulate cortex, bilateral insula, contralateral primary and secondary somatosensory cortices, and ipsilateral cerebellum. Brain regions specifically activated by muscle stimulation were the midbrain, bilateral amygdala, caudate, orbitofrontal cortex, hippocampus, parahippocampus and superior temporal pole, most of which are related to emotion. Regions except the midbrain showed contralateral preference. These results suggest that dull sensation, which is characteristic of muscular pain, is related with processing in these brain regions.


► Painful skin stimulation evoked activation in SI, SII, insula and ACC, as expected.
► Several brain regions were preferentially activated by painful muscle stimulation.
► The regions included the midbrain, bilateral amygdala and orbitofrontal cortex.
► The parahippocampus and superior temporal pole were also activated by muscle pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 70, Issue 3, July 2011, Pages 285–293
نویسندگان
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