CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex

► CB-1 receptor modulates the effect of citalopram. ► CB-1 stimulation blocks the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. ► CB-1 blockade potentiates the effect of citalopram on increasing rat prefrontal cortex 5-HT levels.