کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351729 | 1298079 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords](/preview/png/4351729.png)
چکیده انگلیسی
This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 67, Issue 1, May 2010, Pages 59–64
Journal: Neuroscience Research - Volume 67, Issue 1, May 2010, Pages 59–64
نویسندگان
Kyung Hee Lee, Do Heum Yoon, Myung-Ae Chung, Jin-Hun Sohn, Hye-Jung Lee, Bae Hwan Lee,