کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4351960 1298088 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects
چکیده انگلیسی

Prepulse inhibition (PPI) of acoustic startle reflex (ASR) and personality, such as temperament and character, are considered candidate endophenotypes of schizophrenia. Gene polymorphism studies have provided evidence that both PPI and self-transcendence (ST) are polygenetic traits that involve several neurotransmitters, including the serotonin and dopamine signaling pathways. However, the relationship between PPI and temperament/character has not been properly addressed to date. Here, we investigated the link between PPI and temperament/character in 169 healthy Japanese subjects. A human startle response monitoring system was used to deliver acoustic startle stimuli and to record and score the electromyographic activity of the orbicularis oculi muscle. PPI was evaluated at signal-to-noise ratios (SnRs: intensity difference between background noise and prepulse) of +12, +16, and +20 dB. The lead interval (from prepulse onset to pulse onset) was 120 ms, and Temperament and Character Inventory was used in both groups. Significant correlations at SnR of +16 and +20 dB to ST were identified. Our results suggest that impaired sensorimotor gating, evaluated as lower PPI of ASR, of healthy subjects is correlated with self transcendence, the character which is closely related with schizophrenia and schizotypy.


► We examined the relationship of prepulse inhibition to temperaments and characters.
► Subjects were one hundred and sixty nine healthy Japanese subjects.
► Prepulse inhibition correlated negatively to self-transcendence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 72, Issue 2, February 2012, Pages 187–193
نویسندگان
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