Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro

► 5-HT receptors have different effects on the spine formation of cortical neurons. ► 5-HT1A receptor inhibits the spine maturation. ► 5-HT2A/2C receptor promotes the spine maturation. ► Effects of 5-HT receptors on the spine formation depends on the developmental stages.