کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4352577 | 1298123 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Development of neurons expressing estrogen receptor α transiently in facial nucleus of prenatal and postnatal rat brains Development of neurons expressing estrogen receptor α transiently in facial nucleus of prenatal and postnatal rat brains](/preview/png/4352577.png)
The transient expression of estrogen receptor α (ERα) in the facial nucleus of rats during development was already reported. However, how and whether the receptor functions physiologically in the nucleus of developing rats are as yet unclear. In this study, we applied a retrograde tracer into one of the possible target muscles of the motoneurons in the nucleus, that is, the transverse auricular muscle (Mta), and examined whether ERα-immunopositive neurons take up the tracer. Because it is probable that neurogenesis, apoptosis, and maturation may be associated with the transient expression of ERα, we attempted to analyze the neurons expressing the receptor in the nucleus. We found that ERα-immunopositive neurons in the medial facial subnucleus innervate mostly the Mta. Quantitative analyses showed that the number of motoneurons projecting to the Mta remained the same throughout the ages examined, whereas that of ERα-immunopositive neurons decreased between postnatal days 6 and 11. Apoptosis and neurogenesis in the nucleus were not affected by the expression of ERα during development. ERα expression coincided with the maturation of neurons in the nucleus. Thus, it is possible that ERα expression in the facial nucleus during development plays important roles in the development of motoneurons and/or external pinna muscles.
Journal: Neuroscience Research - Volume 58, Issue 2, June 2007, Pages 190–198