کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4352584 1298125 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microvascular changes in estrogen-α sensitive brainstem structures of aging female hamsters
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Microvascular changes in estrogen-α sensitive brainstem structures of aging female hamsters
چکیده انگلیسی

Structural neuronal plasticity is present in the nucleus para-retroambiguus (NPRA) and the commissural nucleus of the solitary tract/A2 group (NTScom/A2) in female hamsters. Both brainstem nuclei play a role in estrous cycle related autonomic adaptations. We investigated how aging affects the capillary condition in these adaptive brainstem regions. Senescent female hamsters (±95 weeks) were tested weekly for their 4-day estrous cycle. Subsequently morphological changes of NPRA and NTScom/A2 were compared with those of young (±20 weeks) females in an ultrastructural study. The medial tegmental field served as control area. In 841 capillaries (n = 319 capillaries, young females (N = 3); n = 522 capillaries, aged females (N = 4)) vascular aberrations were classified into 3 categories: endothelial and tight junction, basement membrane and pericyte aberrations. In old animals, capillaries showed marked endothelial changes, disrupted tight junctions, and thickening and splitting of basement membranes. Aberrations were found in 40–60% of all capillaries. About 70% of the pericytes contained degenerative inclusions. Despite this generalized vascular degeneration, the reproductive cycle of female hamsters was unaffected by vascular senescence. Perivascular fibrosis as reported in aging rats was never observed, which suggests the existence of species differences.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 67, Issue 4, August 2010, Pages 267–274
نویسندگان
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