کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4352731 1298140 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats
چکیده انگلیسی

In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler flowmetry (LDF) and examined the effect of theophylline, a nonselective adenosine receptor antagonist, on TPS-induced HBF responses. TPS increased HBF, and its response was significantly attenuated by the intraperitoneal administration of theophylline (20 mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 65, Issue 2, October 2009, Pages 156–159
نویسندگان
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