کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4352756 1298141 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Motor deficits and hyperactivity in Dyt1 knockdown mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Motor deficits and hyperactivity in Dyt1 knockdown mice
چکیده انگلیسی

The DYT1 gene containing a trinucleotide deletion (ΔGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded by Dyt1. Knockdown mice exhibited deficits in motor control and a decreased trend in dopamine with a significant reduction in 3,4-dihydroxyphenylacetic acid. These alterations are similar to those displayed by previously reported Dyt1 ΔGAG knockin heterozygous mice, suggesting that the partial loss of torsinA function contributes to the pathology of the disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 56, Issue 4, December 2006, Pages 470–474
نویسندگان
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