Presynaptic nicotinic receptors modulating neurotransmitter release in the Central Nervous System: Functional interactions with other coexisting receptors

▶ nAChRs modulate the function of coexisting presynaptic receptors. ▶ Presynaptic nAChR may interact both with metabotropic or ionotropic receptors. ▶ This co-activation may generate antagonistic or synergistic effects.