کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4353870 | 1298512 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GABA, a forgotten gliotransmitter
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The amino acid γ-aminobutiric acid (GABA) is a major inhibitory transmitter in the vertebrate central nervous system (CNS) where it can be released by neurons and by glial cells. Neuronal GABAergic signaling is well characterized: the mechanisms of GABA release, the receptors it targets and the functional consequences of their activation have been extensively studied. In contrast, the corresponding features of glial GABAergic signaling have attracted less attention. In this review, we first discuss evidence from the literature for GABA accumulation, production and release by glial cells. We then review the results of recent experiments that point toward functional roles of GABA as a “gliotransmitter”.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 86, Issue 3, November 2008, Pages 297–303
Journal: Progress in Neurobiology - Volume 86, Issue 3, November 2008, Pages 297–303
نویسندگان
María Cecilia Angulo, Karim Le Meur, Andrei S. Kozlov, Serge Charpak, Etienne Audinat,