کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4353937 1298523 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological effects of toosendanin, a triterpenoid extracted from Chinese traditional medicine
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Biological effects of toosendanin, a triterpenoid extracted from Chinese traditional medicine
چکیده انگلیسی

Toosendanin (TSN) is a triterpenoid extracted from Melia toosendan Sieb et Zucc, which was used as a digestive tract-parasiticide and agricultural insecticide in ancient China. TSN was demonstrated to be a selective presynaptic blocker and an effective antibotulismic agent. By interfering with neurotransmitter release through an initial facilitation followed by a subsequent depression, TSN eventually blocks synaptic transmission at both the neuro-muscular junction and central synapses. Despite sharing some similar actions with botulinum neurotoxin (BoNT), TSN has a marked antibotulismic effect in vivo and in vitro. Studies suggest that the antibotulismic effect of TSN is achieved by preventing BoNT from approaching its enzymatic substrate, the SNARE protein. It is also found that TSN can induce differentiation and apoptosis in several cell lines, and suppress proliferation of various human cancer cells. TSN inhibits various K+-channels, selectively facilitates Ca2+-influx via L-type Ca2+ channels and increases intracellular Ca2+ concentration ([Ca2+]i). The TSN-induced [Ca2+]i increase and overload could be responsible for the TSN-induced biphasic effect on transmitter release, cell differentiation, apoptosis as well as the cytoxicity of TSN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 82, Issue 1, May 2007, Pages 1–10
نویسندگان
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