کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354197 1299026 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Checks and balances on cholinergic signaling in brain and body function
ترجمه فارسی عنوان
چک کردن و تعادل در سیگنالینگ کولینرژیک در عملکرد مغز و بدن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• ‘Classical’ cholinergic genes are the tip of a recently identified iceberg.
• Pre- and post-transcriptional expanders and restrainers maintain balanced signaling.
• Cholinergic regulators modulate disease risks, addiction, and environment exposure.
• Mutated target genes can interfere with cholinergic miRNA modulations.

A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors, transporters, and synthesizing and degrading enzymes and regulators of their expression as contributors to cognition, metabolism, and immunity. Recent discoveries indicate that pre- and post-transcriptional ACh signaling controllers coordinate the identity, functioning, dynamics, and brain-to-body communication of cholinergic cells. Checks and balances including epigenetic mechanisms, alternative splicing, and miRNAs may all expand or limit the diversity of these cholinergic components by consistently performing genome-related surveillance. This regulatory network enables homeostatic maintenance of brain-to-body ACh signaling as well as reactions to nicotine, Alzheimer's disease anticholinesterase therapeutics, and agricultural pesticides. Here I review recent reports on the functional implications of these controllers of cholinergic signaling in and out of the brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 38, Issue 7, July 2015, Pages 448–458
نویسندگان
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