کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354226 1299031 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Developmental mechanisms channeling cortical evolution
ترجمه فارسی عنوان
مکانیسم های تکاملی تکامل قلب
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Across species, disparity in neuron number per column grows with cortical size.
• A rostrocaudal gradient in neurogenesis duration generates this disparity in neuron number.
• Anisotropies in early axon extension further organize cortical area hierarchy.
• We suggest that the cortex has two zones of contrasting intrinsic topology.
• These mechanisms may progressively amplify hierarchical processing in larger brains.

Increase in the area and neuron number of the cerebral cortex over evolutionary time systematically changes its computational properties. One of the fundamental developmental mechanisms generating the cortex is a conserved rostrocaudal gradient in duration of neuron production, coupled with distinct asymmetries in the patterns of axon extension and synaptogenesis on the same axis. A small set of conserved sensorimotor areas with well-defined thalamic input anchors the rostrocaudal axis. These core mechanisms organize the cortex into two contrasting topographic zones, while systematically amplifying hierarchical organization on the rostrocaudal axis in larger brains. Recent work has shown that variation in ‘cognitive control’ in multiple species correlates best with absolute brain size, and this may be the behavioral outcome of this progressive organizational change.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 38, Issue 2, February 2015, Pages 69–76
نویسندگان
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