کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354228 1299031 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The dynamic pain connectome
ترجمه فارسی عنوان
درد پویا اتصال است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• A dynamic pain connectome represents pain variability encoded in brain communication.
• Specific neural networks contribute to spontaneous pain–attention fluctuations.
• Individual factors and attention contribute to pain connectome disruption in chronic pain.
• Personalized pain therapies may emerge from study of the dynamic pain connectome.

Traditionally, studies of how pain and attention modulate one another involved explicit cognitive-state manipulations. However, emerging evidence suggests that spontaneous brain-wide network communication is intrinsically dynamic on multiple timescales, and attentional states are in constant fluctuation. Here, in light of studies on neural mechanisms of spontaneous attentional fluctuations and pain variability, we introduce the concept of a dynamic ‘pain connectome’ in the brain. We describe how recent progress in our understanding of individual differences in intrinsic attention to pain and neural network dynamics in chronic pain can facilitate development of personalized pain therapies. Furthermore, we emphasize that the dynamics of pain–attention interactions must be accounted for in the contemporary search for a ‘neural signature’ of the pain connectome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 38, Issue 2, February 2015, Pages 86–95
نویسندگان
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