کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4354312 | 1299045 | 2012 | 10 صفحه PDF | دانلود رایگان |
Astroglial excitability is largely mediated by fluctuations in intracellular ion concentrations. In addition to generally acknowledged Ca2+ excitability of astroglia, recent studies have demonstrated that neuronal activity triggers transient increases in the cytosolic Na+ concentration ([Na+]i) in perisynaptic astrocytes. These [Na+]i transients are controlled by multiple Na+-permeable channels and Na+-dependent transporters; spatiotemporally organized [Na+]i dynamics in turn regulate diverse astroglial homeostatic responses such as metabolic/signaling utilization of lactate and glutamate, transmembrane transport of neurotransmitters and K+ buffering. In particular, near-membrane [Na+]i transients determine the rate and the direction of the transmembrane transport of GABA and Ca2+. We discuss here the role of Na+ in the regulation of various systems that mediate fast bidirectional communication between neurones and glia at the single synapse level.
Journal: - Volume 35, Issue 8, August 2012, Pages 497–506