کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354424 1299063 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Serotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression
چکیده انگلیسی

Reports of gene–environment interactions (GxE) between the serotonin transporter gene and stress on risk of depression have generated both excitement and controversy. The controversy persists in part because a mechanistic account of this GxE on serotonergic neurotransmission and risk of depression has been lacking. In this Opinion, we draw on recent discoveries in the functional neuroanatomy of the serotonergic dorsal raphe nucleus (DR) to propose such a mechanistic account. We argue that genetically produced variability in serotonin reuptake during stressor-induced raphe–raphe interactions alters the balance in the amygdala-ventromedial prefrontal cortex (VMPFC)-DR circuitry underlying stressor reactivity and emotion regulation. In particular, the recently characterized stressor-responsive serotonergic interneurons originating from the dorsolateral DR may hold a key to unlocking the GxE mechanism of depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 35, Issue 7, July 2012, Pages 395–402
نویسندگان
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