کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354452 | 1299067 | 2010 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The molecular and gene regulatory signature of a neuron The molecular and gene regulatory signature of a neuron](/preview/png/4354452.png)
Neuron-type specific gene batteries define the morphological and functional diversity of cell types in the nervous system. Here, we discuss the composition of neuron-type specific gene batteries and illustrate gene regulatory strategies which determine the unique gene expression profiles and molecular composition of individual neuronal cell types from C. elegans to higher vertebrates. Based on principles learned from prokaryotic gene regulation, we argue that neuronal terminal gene batteries are functionally grouped into parallel-acting ‘regulons’. The theoretical concepts discussed here provide testable hypotheses for future experimental analysis of the exact gene-regulatory mechanisms employed in the generation of neuronal diversity and identity.
Journal: - Volume 33, Issue 10, October 2010, Pages 435–445