کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354490 | 1299072 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens](/preview/png/4354490.png)
Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic regions of brain thought to be responsible for long-term behavioral plasticity driving addiction. Although these structural changes are well documented in nucleus accumbens medium spiny neurons, little is known regarding the underlying molecular mechanisms. Additionally, it remains unclear whether structural plasticity and its synaptic concomitants drive addictive behaviors or whether they reflect homeostatic compensations to the drug not related to addiction per se. Here, we discuss recent paradoxical data, which either support or oppose the hypothesis that drug-induced changes in dendritic spines drive addictive behavior. We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies.
Journal: - Volume 33, Issue 6, June 2010, Pages 267–276