کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354493 | 1299072 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of trinucleotide-repeat RNA in neurological disease and degeneration
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Roles of trinucleotide-repeat RNA in neurological disease and degeneration Roles of trinucleotide-repeat RNA in neurological disease and degeneration](/preview/png/4354493.png)
چکیده انگلیسی
A large number of human diseases are caused by expansion of repeat sequences – typically trinucleotide repeats – within the respective disease genes. The abnormally expanded sequence can lead to a variety of effects on the gene: sometimes the gene is silenced, but in many cases the expanded repeat sequences confer toxicity to the mRNA and, in the case of polyglutamine diseases, to the encoded protein. This article highlights mechanisms by which the mRNAs with abnormally expanded repeats can confer toxicity leading to neuronal dysfunction and loss. Greater understanding of these mechanisms will provide the foundation for therapeutic advances for this set of human disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 33, Issue 6, June 2010, Pages 292–298
Journal: - Volume 33, Issue 6, June 2010, Pages 292–298
نویسندگان
Ling-Bo Li, Nancy M. Bonini,