کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354498 1299073 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein modifications involved in neurotransmitter and gasotransmitter signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Protein modifications involved in neurotransmitter and gasotransmitter signaling
چکیده انگلیسی

Covalent modifications of intracellular proteins, such as phosphorylation, are generally thought to occur as secondary or tertiary responses to neurotransmitters, following the intermediation of membrane receptors and second messengers such as cyclic AMP. By contrast, the gasotransmitter nitric oxide directly S-nitrosylates cysteine residues in diverse intracellular proteins. Recently, hydrogen sulfide has been acknowledged as a gasotransmitter, which analogously sulfhydrates cysteine residues in proteins. Cysteine residues are also modified by palmitoylation in response to neurotransmitter signaling, possibly in reciprocity with S-nitrosylation. Neurotransmission also elicits sumoylation and acetylation of lysine residues within diverse proteins. This review addresses how these recently appreciated protein modifications impact our thinking about ways in which neurotransmission regulates intracellular protein disposition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 33, Issue 11, November 2010, Pages 493–502
نویسندگان
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