کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354531 | 1299077 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Critical role of nociceptor plasticity in chronic pain Critical role of nociceptor plasticity in chronic pain](/preview/png/4354531.png)
The transition from acute to chronic pain states might be the most important challenge in research to improve clinical treatment of debilitating pain. We describe a recently identified mechanism of neuronal plasticity in primary afferent nociceptive nerve fibers (nociceptors) by which an acute inflammatory insult or environmental stressor can trigger long-lasting hypersensitivity of nociceptors to inflammatory cytokines. This phenomenon, “hyperalgesic priming,” depends on the epsilon isoform of protein kinase C (PKCɛ) and a switch in intracellular signaling pathways that mediate cytokine-induced nociceptor hyperexcitability. We discuss the impact of this discovery on our understanding of, and ultimately our ability to treat, a variety of enigmatic and debilitating pain conditions, including those associated with repetitive injury, and generalized pain conditions, such as fibromyalgia.
Journal: - Volume 32, Issue 12, December 2009, Pages 611–618