کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354762 | 1299106 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphatase PTEN in neuronal injury and brain disorders
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Phosphatase PTEN in neuronal injury and brain disorders Phosphatase PTEN in neuronal injury and brain disorders](/preview/png/4354762.png)
چکیده انگلیسی
The phosphatase and tensin homologue PTEN was originally identified as a tumor suppressor. In the CNS, mutation or inactivation of PTEN is best known for playing a tumorigenic role in the molecular pathogenesis of glioblastoma. However, recent studies show that PTEN is associated with several brain diseases other than cancer, suggesting a broader role of PTEN in CNS pathophysiology. Here, we review the evidence for the crucial involvement of PTEN in neuronal injury as well as in neurological and psychiatric disorders, and discuss the potential of PTEN as a molecular target for the development of a novel CNS therapeutic strategy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 30, Issue 11, November 2007, Pages 581–586
Journal: - Volume 30, Issue 11, November 2007, Pages 581–586
نویسندگان
Ning Chang, Youssef H. El-Hayek, Everlyne Gomez, Qi Wan,