کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354898 1299121 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hippocampal long-term depression: master or minion in declarative memory processes?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Hippocampal long-term depression: master or minion in declarative memory processes?
چکیده انگلیسی

The neural mechanisms for the formation of declarative memory (memory for facts and events) are believed to be integrated from processes mediated by hippocampal long-term potentiation (LTP) and long-term depression (LTD). Traditionally, LTP has been designated as the main mediator of spatial memory storage in the hippocampus, whereas LTD has been assigned an auxiliary role in signal-to-noise regulation or in forgetting. It has recently become apparent, however, that LTD contributes directly to hippocampal information storage. In fact, LTD could dominate in the processing of precise spatial characteristics. Accumulating evidence supports the idea that LTP and LTD enable distinct and separate forms of information storage, which together facilitate the generation of a spatial cognitive map.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 30, Issue 3, March 2007, Pages 111–118
نویسندگان
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