کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354908 | 1299123 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imaging synaptic zinc: promises and perils
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
It is well established that some excitatory nerve terminals have high concentrations of Zn2+ in their synaptic vesicles. For some time, it has been believed that synaptic Zn2+ is released during neurotransmission and acts as a neuromodulator. Fluorescent Zn2+ indicators that do not penetrate membranes offer the prospect of rendering the release of Zn2+ visible. Here, I take a critical look at fluorimetric imaging experiments devised to determine whether Zn2+ is released and show that they are particularly susceptible to artifacts. Moreover, I will argue that recent experiments suggest that, rather than being released, Zn2+ is presented to the extracellular space firmly coordinated to presynaptic macromolecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 29, Issue 4, April 2006, Pages 200–206
Journal: - Volume 29, Issue 4, April 2006, Pages 200–206
نویسندگان
Alan R. Kay,